Contrasting Properties of Polymeric Nanocarriers for MRI-Guided Drug Delivery

Poor pharmacokinetics and low aqueous solubility combined with rapid clearance from the circulation of drugs result in their limited effectiveness generally high therapeutic doses. The use nanocarriers for drug delivery can prevent degradation drug, leading to its increased half-life. It also improve stability drugs, advance distribution targeting, ensure a sustained release, reduce resistance by delivering multiple agents simultaneously. Furthermore, nanotechnology enables combination therapeutics biomedical imaging other treatment modalities overcome challenges disease diagnosis therapy. Such an approach is referred as “theranostics” aims offer more patient-specific through observation contrast that are linked therapeutics. purpose this paper present recent scientific reports on polymeric MRI-guided delivery. Polymeric very broad versatile group materials delivery, providing loading capacities, improved pharmacokinetics, biocompatibility. main focus was contrasting properties proposed nanocarriers, which be categorized into three groups: (1) relaxation-type agents, (2) chemical exchange saturation transfer (CEST) properties, (3) direct detection based fluorinated compounds. importance aspect tends downplayed, despite being essential successful design applicable theranostic image-guided If available, cytotoxicity effects were summarized.